Clinical inquiries. Does low-dose aspirin reduce preeclampsia and other maternal-fetal complications?

yes. The use of low-dose aspirin during pregnancy decreases the risk of preeclampsia for women considered at increased risk. The effect is smaller for women without risk factors (strength of recommendation [sor]: a, based on randomized controlled trials [rCTs] and systematic reviews [srs] of rCTs). rates of preterm delivery, perinatal death, and incidence of small-forgestational age infants are decreased for women treated with low-dose aspirin (sor: a, based on srs and rCTs). a metaanalysis of rCTs has found no increased rates of harm from low-dose aspirin therapy, including placental abruption or other antepartum bleeding complications (sor: a, based on srs and rCTs).